USP7: Novel Drug Target in Cancer Therapy

USP7: Novel Drug Target in Cancer Therapy

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Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site cardinals 3.14 flash sale to a catalytically competent state by the C-terminal peptide.Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodeling, and epigenetic regulation.Aberrant activation or overexpression of USP7 may promote oncogenesis and viral disease, making it a target for therapeutic intervention.

Currently, several synthetic small molecules have been identified as inhibitors leather baton holder of USP7, and applied in the treatment of diverse diseases.Hence, USP7 may be a promising therapeutic target for the treatment of cancer.